The mission of the National Institute of General Medical Sciences (NIGMS) is to support research that increases understanding of life processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. NIGMS provides funding for fundamental research in many scientific areas relevant to human health, including organic chemistry, high-throughput synthesis and chemical biology. Chicago CMLD is supported by NIGMS (P50-GM086145).
The Molecular Libraries Small Molecule Repository (MLSMR) is designed to identify, acquire, maintain, and distribute to the Molecular Libraries Screening Centers Network (MLSCN)an eventual collection of approximately 500,000 chemically diverse compounds with known or unknown biological activities for use in high-throughput screening (HTS) of a diverse set of biological assays submitted by the research community and implemented within the centers. It is anticipated that a subset of the screening “hits” that are generated will be further developed by the MLSCN into optimized chemical analogs that can be used by the scientific community as bioactive Probe Guidelines to study molecular targets and cellular pathways, and potentially as starting points for therapeutics development outside of the MLSCN. The chemical structures of the compounds in the repository, along with the associated screening data obtained from the MLSCN, will be shared with the public through PubChem.
The CTCMLD received partial funding from the Searle Funds at the Chicago Community Trust. The Searle Funds at The Chicago Community Trust has made a grant of $5 million to the Chicago Biomedical Consortium (CBC), a collaboration of Northwestern University, the University of Chicago and the University of Illinois at Chicago. The grant, the first of a planned five-year donation of $5 million per year for a total of $25 million, is designed to support and stimulate innovative multi-institutional collaborations in research and education that will enable the Chicago area to become a leader in the biomedical sciences.
The mission of the CBC is to stimulate collaboration among scientists at Northwestern University, the University of Chicago, and the University of Illinois at Chicago that will transform research at the frontiers of biomedicine.
The OSIRIS Property Explorer is an integral part of Actelion's (1) inhouse substance registration system. It lets you draw chemical structures and calculates on-the-fly various drug-relevant properties whenever a structure is valid. Prediction results are valued and color coded.
Molinspiration is an independent research organization focused on development and application of modern cheminformatics techniques, especially in connection with the internet.
The Virtual Computational Chemistry Laboratory uses multi-platform software allowing the computational chemist to perform a comprehensive series of molecular properties calculations and data analysis on Internet. The software will be based on three-tier architecture that is becoming widespread to provide client-server services over the world.
PubChem provides information on the biological activities of small molecules. It is a component of NIH's Molecular Libraries Roadmap Initiative.
ChemBank is a public, web-based informatics environment created by the Broad Institute's Chemical Biology Program and funded in large part by the National Cancer Institute's Initiative for Chemical Genetics (ICG). This knowledge environment includes freely available data derived from small molecules and small-molecule screens, and resources for studying the data so that biological and medical insights can be gained. ChemBank is intended to guide chemists synthesizing novel compounds or libraries, to assist biologists searching for small molecules that perturb specific biological pathways, and to catalyze the process by which drug hunters discover new and effective medicines.
The World Drug Index is the index for developed and marketed drugs in the world.